Consumo di frutta e verdura e tumore al pancreas

Jansen RJ, Robinson DP, Stolzenberg-Solomon RZ, Bamlet WR, de Andrade M, Oberg AL, Hammer TJ, Rabe KG, Anderson KE, Olson JE, Sinha R, Petersen GM.
Cancer Causes Control. 2011 Sep 14. [Epub ahead of print]

14-09-2011

Numerose evidenze epidemiologiche supportano l’associazione tra il consumo regolare di frutta e verdura e la riduzione del rischio di diversi tipi di tumore.
In questo studio le abitudini alimentari di 384 pazienti con diagnosi di tumore al pancreas sono state confrontate con quelle di 983 soggetti di controllo, soprattutto per quanto riguarda il consumo di frutta, verdura, cereali e legumi.
Dalla comparazione del più alto quintile di consumo di vegetali con il più basso è emersa un’associazione inversa statisticamente significativa per gli agrumi,il melone, i frutti di bosco, i vegetali verdi e gialli, i pomodori, i fagioli, i piselli, le fibre solubili e insolubili, i cereali integrali, i succhi di arancia e di uva (odds ratio < 0.8).
Queste osservazioni suggeriscono che un consumo insufficiente di frutta e verdura e di cereali integrali e fibra possa aumentare il rischio di cancro al pancreas e confermano l’efficacia della correzione in prevenzione primaria.

Lifestyle factors and risk for new-onset diabetes: a population-based cohort study.

Background: Epidemiologic data on the combined influence of several lifestyle factors on diabetes risk are rare, particularly among older adults. Objective: To examine how combinations of lifestyle risk factors relate to the 11-year risk for incident diabetes. Design: Population-based prospective cohort study. Setting: National Institutes of Health (NIH)-AARP Diet and Health Study. Participants: 114 996 men and 92 483 women, aged 50 to 71 years in 1995 to 1996, without evidence of heart disease, cancer, or diabetes. Measurements: A comprehensive survey of demographic characteristics and lifestyle factors, including dietary intake, body weight and height, physical activity, smoking, and alcohol consumption at baseline (1995 to 1996). Low-risk groups were formed by dichotomizing each lifestyle factor. Incident self-reported, physician-diagnosed diabetes was identified with a follow-up survey in 2004 to 2006. Results: 11 031 men (9.6%) and 6969 women (7.5%) developed new-onset diabetes. For each additional lifestyle factor in the low-risk group, the odds for diabetes were 31% lower (odds ratio [OR], 0.69 [95% CI, 0.68 to 0.71]) among men and 39% lower (OR, 0.61 [CI, 0.60 to 0.63]) among women. Men and women whose diet score, physical activity level, smoking status, and alcohol use were all in the low-risk group had ORs for diabetes of 0.61 (CI, 0.56 to 0.66) and 0.43 (CI, 0.34 to 0.55), respectively. When absence of overweight or obesity was added, the respective ORs were 0.28 (CI, 0.23 to 0.34) and 0.16 (CI, 0.10 to 0.24) for men and women. Results did not differ by family history of diabetes or level of adiposity. Limitation: The study was observational, with potential for residual confounding. Conclusion: Lifestyle factors, when considered in combination, are associated with a substantial reduction in risk for diabetes.

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